Effects of topical application of platelet-rich plasma on esophageal stricture and oxidative stress after caustic burn in rats: Is autologous treatment possible?
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In brief
In brief
Experimental rat study evaluating topical platelet-rich plasma (PRP) application to prevent esophageal stricture formation after caustic NaOH burn. Results demonstrate PRP reduces stenosis index, improves weight gain, and modulates oxidative stress markers compared to untreated burn controls, suggesting potential for autologous treatment in pediatric caustic injury.
Written by the GCMD Library team from the article.
Background
Caustic esophageal burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after caustic esophageal injury in rats.
Methods
Twenty-one rats were divided into three groups [Sham operation (n = 8), corrosive esophageal burn with 30% NaOH (n = 6), topical PRP application after corrosive burn (n = 7)]. On the postoperative 21st day, oxidative markers were measured in the serum, and collagen accumulation and stenosis index were measured histopathologically to assess the efficacy of PRP treatment.
Results
Postoperative weight was higher than preoperative weight in Sham and PRP groups, but lower in the Burn group (p