Effect of Wilms tumor histology on response to neoadjuvant chemotherapy
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In brief
In brief
Retrospective study of 52 Wilms tumor patients (1988-2015) examining the relationship between tumor histology at diagnosis and volumetric response to preoperative chemotherapy. Median tumor volume decreased 68% with neoadjuvant treatment, with analysis correlating histologic subtypes to radiographic response patterns.
Written by the GCMD Library team from the article.
Purpose
To evaluate the association between Wilms tumor histology at diagnosis and the change in Wilms' tumor volume during preoperative chemotherapy.
Methods
We included all the 52 patients operated for Wilms tumor at 1988–2015, who had both pathology samples and either CT or MRI-images before and after preoperative chemotherapy, available for reevaluation.
Results
The median tumor volume was 586 ml (IQR 323–903) at diagnosis. The median change in tumor volume was −68% (IQR −85 to −40, p