Effect of intraoperative fluid type on postoperative systemic inflammatory response and end-organ dysfunction following total pancreatectomy with islet autotransplantation in children
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In brief
In brief
Retrospective study comparing half-normal saline versus lactated Ringer's solution during total pancreatectomy with islet autotransplantation in 43 pediatric patients. Intraoperative fluid type did not significantly affect postoperative SIRS or acute kidney injury rates, though SIRS was highly prevalent across both groups in the early postoperative period.
Written by the GCMD Library team from the article.
Purpose
To evaluate the effect of intraoperative fluid type [half-normal saline (0.45NS) or lactated Ringer's solution (LR)] on the risk of systemic inflammatory response syndrome (SIRS) and acute kidney injury after total pancreatectomy with islet autotransplantation in children.
Methods
Retrospective review where demographics, operative details, systemic inflammatory response, and evaluation for end-organ dysfunction over the first 5 postoperative days was obtained. Mixed-effects Poisson regression compared risk of SIRS and acute kidney injury by intraoperative fluid type.
Results
Forty-three patients were included with no difference in demographic characteristics between groups. SIRS was observed in 95%, 77%, and 71% over post-operative days 1, 3, and 5. Intraoperative fluid type was found to not be associated with postoperative SIRS (RR: 0.91, p=0.23). However, female sex (RR: 1.30, p