Early enteral feeding versus traditional feeding in neonatal congenital gastrointestinal malformation undergoing intestinal anastomosis: A randomized multicenter controlled trial of an Enhanced Recovery After Surgery (ERAS) component
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In brief
In brief
Multicenter RCT comparing early enteral feeding to traditional feeding in 156 neonates after intestinal anastomosis for congenital GI malformations. Early feeding proved safe with trends toward reduced hospital stay and faster time to full feeds, supporting its use as an ERAS component in this population.
Written by the GCMD Library team from the article.
Abstract
Purpose
the aim of this clinical trial was to evaluate the safety and efficacy of early enteral feeding (EEN) following intestinal anastomosis in neonates with congenital gastrointestinal malformation.
Methods
a multicenter, prospective, randomized controlled trial (registered under chictr.org.cn Identifier no.ChiCTR-INR-17014179) was conducted between 2018 and 2019. Four centers in China analyzed 156 newborns of congenital gastrointestinal malformation undergoing intestinal anastomosis to EEN group (n = 78) or control (C) group (n = 78). The primary outcomes of this study were length of postoperative stay (LOPS) and time to full feeds. Secondary outcomes included morbidity of complications, parenteral nutrition (PN) duration, feeding intolerance, 30 day mortality rate and 30 day readmission rate.
Results
the mean time to full feeds and LOPS in the EEN group were 15.0 (9.8–22.8) days and 17.6 (12.0–29.8) days, while that were 18.0 (12.0–24.0) days and 20.0 (15.0–30.3) days in C groups respectively. There was no significant difference between two groups(P >0.05). No significant intergroup difference was found with respect to postoperative morbidity, PN duration or feeding intolerance(P >0.05).
Conclusions
early enteral feeding following intestinal anastomosis in neonates with congenital gastrointestinal malformation is safe. Post-operative outcomes demonstrated a trend toward improvement.
Level of evidence
Level Ⅰ.