Michael Helmrath · Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion
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Article1 min read·Published Nov 2026

Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion

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Article · Nov 2026 · 1 min read

In brief

In brief

This study investigates the timing-dependent effects of GLP-2 administration on intestinal stem cell expansion following ileo-cecal resection. Results demonstrate that early GLP-2 treatment augments stem cell proliferation during the critical adaptive window, while delayed administration shows no benefit.

Written by the GCMD Library team from the article.

Michael Helmrath

Expansion of intestinal progenitors and putative stem cells (pISC) occurs early and transiently following ileo-cecal resection (ICR). The mechanism controlling this process is not defined. We hypothesized that glucagon-like peptide-2 (GLP-2) would augment jejunal pISC expansion only when administere …

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