Drug-induced secretory diarrhea: A role for CFTR.
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This article explores the role of CFTR chloride channels in medication-induced secretory diarrhea, a common and potentially serious side effect that limits therapeutic efficacy. Understanding CFTR's mechanism in intestinal fluid secretion may inform strategies to prevent or manage drug-induced diarrhea.
Written by the GCMD Library team from the article.
Statements in this article
Many medications induce diarrhea as a side effect, which can be a major obstacle to therapeutic efficacy and also a life-threatening condition.
Secretory diarrhea can be caused by excessive fluid secretion in the intestine under pathological conditions.
The cAMP/cGMP-regulated cystic fibrosis transmembrane conductance regulator (CFTR) is the primary chloride channel at the apical membrane of intestinal epithelial cells.