Down Syndrome and Postoperative Complications in Children Undergoing Intestinal Operations
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In brief
In brief
Retrospective cohort study using 2012 Kids' Inpatient Database examining postoperative outcomes in 444 pediatric patients with Down syndrome versus 16,582 controls undergoing intestinal operations. Analysis employs inverse probability weighting to compare medical/surgical complications and mortality rates between groups.
Written by the GCMD Library team from the article.
Objective
This paper intends to evaluate the association between Down Syndrome (DS) and postoperative medical and surgical complications and inpatient postoperative mortality in pediatric patients undergoing intestinal operations.
Methods
The 2012 Kids' Inpatient Database was queried to compare short-term postoperative medical and surgical complications and in-patient mortality among patients with DS undergoing intestinal operations to a cohort without DS using inverse probability weighting. Subset analysis was performed for patients undergoing intestinal operations exclusive of gastrostomy placement. Adverse treatment effects were calculated for the outcomes of interest.
Results
Of 17,026 pediatric patients undergoing intestinal operations, 444 had DS. In unadjusted analysis, medical complications (urinary tract infection, deep venous thrombosis, sepsis, pneumonia) occurred in 7.9% of patients with DS, compared to 14.1% of those without (p