Double plication for spring-mediated intestinal lengthening of a defunctionalized Roux limb
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In brief
In brief
Experimental study in juvenile pigs demonstrating that double suture plication can confine nitinol springs within a defunctionalized Roux limb while maintaining luminal patency. Compressed springs achieved 1.7-fold intestinal lengthening over 3 weeks, suggesting potential application for short bowel syndrome treatment.
Written by the GCMD Library team from the article.
Background
Spring-mediated distraction enterogenesis has been shown to increase the length of an intestinal segment. The goal of this study is to use suture plication to confine a spring within an intestinal segment while maintaining luminal patency to the rest of the intestine.
Methods
Juvenile mini-Yucatan pigs underwent placement of nitinol springs within a defunctionalized Roux limb of jejunum. A 20 French catheter was passed temporarily, and sutures were used to plicate the intestinal wall around the catheter at both ends of the encapsulated spring. Uncompressed springs placed in plicated segments and springs placed in nonplicated segments served as controls. The intestine was examined approximately 3 weeks after spring placement.
Results
In the absence of plication, springs passed through the intestine within a week. Double plication allowed the spring to stay within the Roux limb for 3 weeks. Compared to uncompressed springs that showed no change in the length of plicated segments, compressed springs caused a significant 1.7-fold increase in the length of plicated segments.
Conclusions
Intestinal plication is an effective method to confine endoluminal springs. The confined springs could lengthen intestine that maintains luminal patency. This approach may be useful to lengthen intestine in patients with short bowel syndrome.
Level of Evidence
Level I Experimental Study.