Does the identity of the bacteria matter in post-Kasai cholangitis? A comparison between simple and intractable cholangitis
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In brief
In brief
Retrospective study of 192 post-Kasai patients comparing simple versus intractable cholangitis episodes. Intractable cholangitis occurs more frequently in the first postoperative year with different bacterial profiles; positive blood cultures in intractable cases correlate with significantly improved native liver survival (100% vs 20%), emphasizing the importance of microbiological diagnosis.
Written by the GCMD Library team from the article.
Purpose
This study compared the bacteriology and clinical outcomes between simple (SC) and intractable cholangitis (IC) after Kasai operation.
Methods
Post-Kasai patients (n = 192) from 1980 to 2015 were retrospectively reviewed. The results of blood culture and clinical outcomes between the patients with SC and IC were compared.
Main results
A total of 102 cholangitic episodes in 68 patients were analyzed (SC vs IC = 76 vs 26). There were more IC episodes within the first year of Kasai operation (SC vs IC = 36.8% vs 61.5%, p = 0.022). The most common bacteria identified in SC and IC groups were Escherichia Coli and Staphylococcus aureus. Until the latest follow up, the native liver survival rates in patients with SC and IC were 75.0% and 50.0% (p = 0.89). Among the patients with IC, the native liver survival rate was significantly better in those with a positive culture (100% vs 20%, p = 0.001).
Conclusion
Intractable cholangitis is a common complication within the first year of Kasai operation and may be caused by a different spectrum of organisms. The identification of the bacteria by blood culturing may result in a better treatment outcome.
Level of evidence
Level III.