Distraction enterogenesis in the murine colon
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Read the article on jpedsurg.org ↗Article · Oct 2021 · 1 min read
In brief
In brief
Experimental study demonstrates that compressed nitinol springs inserted into murine cecum achieve 150% colonic lengthening over 14 days, with associated muscularis thickening. This proof-of-concept extends distraction enterogenesis technology from small to large intestine, offering potential therapeutic applications for pediatric intestinal diseases requiring bowel lengthening.
Written by the GCMD Library team from the article.
Background/Purpose
Distraction enterogenesis with intraluminal spring technology has been successfully used to lengthen segments of murine small intestine. We hypothesized that biocompatible springs could also be used to lengthen murine large intestine.
Methods
Age and weight matched C57BL/6 mice underwent surgical insertion of nitinol spring-loaded capsules into the cecum. Segment lengths were measured at initial spring placement and at euthanasia after 7 and 14 days. Histologic adaptations were evaluated at scarification.
Results
Cecal segments loaded with compressed springs lengthened an average of 150%, which was significantly longer than control segments loaded with either empty capsules or uncompressed springs. Muscularis layers tended to be thicker in the compressed spring groups compared to control groups.
Conclusions
Insertion of a compressed nitinol spring into the cecum results in significant colonic lengthening in a mouse model. The ability to increase cecum length serves as proof of concept that distraction enterogenesis technology may be feasibly applied to large intestinal models. The use of distraction enterogenesis technology shows promise for application to clinical models in the treatment of pediatric intestinal disease.