Development of venous thrombi in a pediatric population of intestinal failure
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In brief
In brief
This study examined risk factors for venous thrombosis in pediatric intestinal failure patients on long-term parenteral nutrition. Children with NEC or gastroschisis who required multiple central line placements in early life had significantly higher thrombosis rates, identifying targets for preventive interventions.
Written by the GCMD Library team from the article.
Background/Purpose
Although pediatric intestinal failure (IF) is now a survivable diagnosis, children are still at risk for complications. Loss of venous access persists as a leading indication for intestinal transplantation. The goal of this study was to identify risk factors for loss of venous access in a pediatric intestinal failure population on long-term PN.
Methods
We identified all patients who were PN dependent.
Results
Patients that developed venous thrombosis had significantly more lines placed in the first 2 years of life compared to those who did not develop thrombosis. Multivariate regression analysis revealed that diagnosis (NEC and gastroschisis) and parental education were significant predictors of venous thrombosis.
Conclusion
By identifying potential risk factors for thrombus development, interventions can be developed to improve the overall outcome in pediatric IF patients.
Type of Study
Diagnostic
Level of Evidence
III