Determination of Factors to Distinguish MIS-C from Acute Appendicitis in Children with Acute Abdominal Pain
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In brief
In brief
This study identifies clinical and laboratory markers to differentiate MIS-C from acute appendicitis in children presenting with acute abdominal pain. Key distinguishing features include longer symptom duration, high-grade fever, lymphopenia, and elevated inflammatory markers in MIS-C patients versus appendicitis cases.
Written by the GCMD Library team from the article.
Introduction The aim of this study was to make the differential diagnosis between acute appendicitis and multisystem inflammatory syndrome in children (MIS-C) for patients presenting with the complaint of acute abdominal pain (AAP) and to identify the determining factors for the diagnosis of MIS-C.
Materials and Methods Eighty-one children presenting with AAP/suspected AAP were evaluated. Of these, 24 (29.6%) were included in the MIS-C group (MIS-C/g) and 57 were included in the suspected appendicitis group (S-A/g), which consisted of two subgroups: appendicitis group (A/g) and control observation group (CO/g).
Results Comparing MIS-C/g, A/g, and CO/g, duration of abdominal pain (2.4, 1.5, 1.8 days), high-grade fever (38.8, 36.7, 37°C), severe vomiting, and severe diarrhea were higher in MIS-C/g. Lymphocytes count (LC) was lower, while values of C-reactive protein (CRP), ferritin, and coagulopathy were higher in MIS-C/g (p