Article1 min read·Published May 2022Older

Demographic and Clinical Characteristics Associated With the Failure of Nonoperative Management of Uncomplicated Appendicitis in Children: Secondary Analysis of a Nonrandomized Clinical Trial

Part of Pediatric Appendicitis Management 4 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Importance: The factors associated with the failure of nonoperative management of appendicitis and the differences in patient-reported outcomes between successful and unsuccessful nonoperative management remain unknown. Objectives: To investigate factors associated with the failure of nonoperative management of appendicitis and compare patient-reported outcomes between patients whose treatment succeeded and those whose treatment failed. Design, Setting, And Participants: This study was a planned subgroup secondary analysis conducted in 10 children's hospitals that included 370 children aged 7 to 17 years with uncomplicated appendicitis enrolled in a prospective, nonrandomized clinical trial between May 1, 2015, and October 31, 2018, with 1-year follow-up comparing nonoperative management with antibiotics vs surgery for uncomplicated appendicitis. Statistical analysis was performed from November 1, 2019, to February 12, 2022. Interventions: Nonoperative management with antibiotics vs surgery. Main Outcomes And Measures: Failure of nonoperative management and patient-reported outcomes. The relative risk (RR) of failure based on sociodemographic and clinical characteristics was calculated. Patient-reported outcomes were compared based on the success or failure of nonoperative management. Results: Of 370 patients (34.6% of 1068 total patients; 229 boys [61.9%]; median age, 12.3 years [IQR, 10.0-14.6 years]) enrolled in the nonoperative group, treatment failure occurred for 125 pa

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Article · May 2022 · 1 min read

In brief

This multicenter study analyzed 370 children with uncomplicated appendicitis treated nonoperatively to identify factors predicting treatment failure and compare outcomes between successful and failed cases. The research provides evidence on which patients are most likely to succeed with antibiotic management versus requiring surgery.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

The study enrolled 370 children aged 7 to 17 years with uncomplicated appendicitis in a prospective, nonrandomized clinical trial between May 1, 2015, and October 31, 2018, with 1-year follow-up.
ResearchDesign, Setting, And Participants
Of 370 patients enrolled in the nonoperative group, treatment failure occurred for 125 patients.
ResearchResults
The median age of enrolled patients was 12.3 years (IQR, 10.0-14.6 years) and 61.9% were boys.
ResearchResults

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