Correlation of ectopic distal location of papilla of Vater and clinical characteristics in pediatric choledochal cysts
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In brief
In brief
This study of 327 pediatric choledochal cyst patients demonstrates that more distal ectopic location of the papilla of Vater correlates with larger cysts, younger age at presentation, higher prenatal detection rates, and more severe liver fibrosis. Findings suggest papillary location plays a key role in disease pathogenesis and severity.
Written by the GCMD Library team from the article.
Abstract
Purpose
Ectopic distal location of papilla of Vater (EDLPV) is an obvious pathological feature of choledochal cyst (CDC). This study aimed to investigate the correlation between EDLPV and clinical characteristics of CDCs.
Methods
Three groups were studied: Group 1 (G1), papilla in the middle third of second part of duodenum (n = 38); Group 2 (G2), papilla from the distal third of second part to the beginning of third part of duodenum (n = 168); Group 3 (G3), papilla from the middle of third part to fourth part of duodenum (n = 121). Relative variables among three groups were compared.
Results
Compared with G1 and G2, G3 patients had the largest cysts (relative diameter: 1.18 vs. 1.60 vs. 2.62, p < 0.001), the youngest age (20.52 vs. 19.47 vs. -3.40 months, p < 0.001), the highest rate of prenatal diagnosis (26.32% vs. 36.31% vs. 62.81%, p < 0.001), the lowest occurrence of protein plugs in common channel (44.74% vs. 38.69% vs. 16.53%, p < 0.001), and the most elevated total bilirubin level (7.35 vs. 9.95 vs. 28.70 μmol/L, p < 0.001). Prenatally diagnosed G3 patients had heavier liver fibrosis than G2 (13.16% vs. 1.67%, p = 0.015).
Conclusion
The more distal papilla location, the more severe clinical characteristics of CDCs, suggesting a crucial role in its pathogenesis.