Contemporary Outcomes for Infants with Necrotizing Enterocolitis-A Systematic Review.
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In brief
In brief
This systematic review analyzed 38 studies (2010-2018) examining outcomes for infants with necrotizing enterocolitis in high-income countries. Overall mortality was 23.5% for confirmed NEC, rising to 34.5% for surgical cases and 40.5% for extremely low birthweight infants, providing evidence-based data for counseling families and guiding clinical care.
Written by the GCMD Library team from the article.
OBJECTIVE: To develop an accurate understanding of outcomes for necrotizing enterocolitis (NEC) to inform parental counseling, clinical care, and research agendas.
STUDY DESIGN: A systematic review of recent (January 2010-January 2018) large cohort studies reporting outcomes of infants who developed NEC. Only studies reporting national, regional, or multicenter outcomes of NEC in high income countries were included. Outcomes assessed were mortality, neurodevelopmental outcome, and intestinal failure. Meta-analyses were used to generate summary statistics for these outcomes.
RESULTS: Of 1375 abstracts, 38 articles were included. Overall mortality was 23.5% in all neonates with confirmed NEC (Bell stage 2a+) (95% CI 18.5%-28.8%), 34.5% (30.1%-39.2%) for neonates that underwent surgery for NEC, 40.5% (37.2%-43.8%) for extremely low birthweight infants (