Congenital heart disease associated with congenital diaphragmatic hernia: A systematic review on incidence, prenatal diagnosis, management, and outcome
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In brief
In brief
Systematic review of 28,974 CDH cases reveals 15% have associated congenital heart disease, with 42% classified as critical. Infants with CHD underwent CDH repair less frequently (72% vs 85%) and faced significantly higher mortality, highlighting the prognostic importance of cardiac screening in CDH management.
Written by the GCMD Library team from the article.
Purpose
The purpose of this study was to evaluate the impact of congenital heart disease (CHD) on infants with congenital diaphragmatic hernia (CDH).
Methods
Using a defined search strategy (PubMed, Cochrane, Embase, Web of Science MeSH headings), we searched studies reporting the incidence, management, and outcome of CDH infants born with associated CHD.
Results
Of 6410 abstracts, 117 met criteria. Overall, out of 28,974 babies with CDH, 4427 (15%) had CHD, of which 42% were critical. CDH repair was performed in a lower proportion of infants with CHD (72%) than in those without (85%; p