Complex lymphatic anomalies: Molecular landscape and medical management

In brief

This article reviews the molecular mechanisms underlying complex lymphatic anomalies, particularly PIK3CA-related overgrowth disorders, and evidence-based medical management strategies. It addresses targeted therapies including mTOR inhibitors like sirolimus, providing clinicians with current approaches to managing these challenging vascular malformations in pediatric patients.

Written by the GCMD Library team from the article.