Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center
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In brief
In brief
Retrospective analysis of 58 neonates with complex gastroschisis at a referral center reveals significantly prolonged parenteral nutrition duration (92 vs 32 days) and hospital stay (119 vs 42 days) compared to uncomplicated cases. Complications included intestinal necrosis, atresia, NEC, and severe GERD, with outcomes varying by complication type.
Written by the GCMD Library team from the article.
Aim of the study
To evaluate the outcomes of neonates with complex gastroschisis (GC), and correlate outcomes with each type of complication.
Methods
Retrospective review of patients with complex GC owing to prenatal and/or postnatal abdominal complications; 2008–2016. Primary outcomes: time to discontinue parenteral nutrition (off-PN), length of stay (LOS) and neonatal survival.
Main results
We treated 58 patients with complex gastroschisis owing to abdominal complications, which were: intestinal necrosis at birth (n=9), intestinal atresia (n=16), medical necrotizing enterocolitis (NEC) (n=15), surgical NEC (n=1), in utero volvulus (n=1), vanishing gastroschisis (n=2), severe intestinal dysmotility (n=1), delayed abdominal closure (n=3), abdominal compartment syndrome (n=2) and hiatal hernia/severe gastroesophageal reflux disease (GERD; n=11). The off-PN time and LOS of the whole group were 92 (35–255) and 119 (42–282) days, significantly longer than those of a demographically equivalent contemporaneous series of 125 patients with uncomplicated gastroschisis (off-PN 32 [12–105] days [p