Comparison of postoperative chylothorax in infants and children with trisomy 21 and without dysmorphic syndrome: Is there a difference in clinical outcome?
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In brief
In brief
Retrospective study of 2,255 pediatric cardiac surgery patients found children with trisomy 21 develop postoperative chylothorax at significantly higher rates (16.9%) compared to those without dysmorphic syndromes (3%). The study analyzes differences in chyle composition, volume, and duration to characterize lymphatic complications in Down syndrome patients.
Written by the GCMD Library team from the article.
Introduction
Children with trisomy 21 are prone to postoperative chylothorax, caused by malformation of the lymphatic system, after cardiac surgery. The clinical course of patients diagnosed with postoperative chylothorax and trisomy 21 was compared to that of patients without dysmorphic syndromes. Additionally, differences between the groups in composition, amount, and duration of chyle were analyzed to better understand chylothorax in patients with trisomy 21.
Materials and methods
Retrospective cohort study using inpatient clinical databases during a 10-year period.
Results
A total of 2255 patients underwent cardiac operations during the period, of whom 160 (7.1%) patients were diagnosed with trisomy 21. Chylothorax developed in 122 children; 89 patients were included in our study. Of 160 trisomy 21 patients, 27 (16.9%) developed postoperative chylothorax compared to 62 (3%) of 2095 patients without dysmorphic syndromes (p =