Comparing quality of life improvement after antegrade continence enema (ACE) therapy for patients with organic and functional constipation / encopresis
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Read the article on jpedsurg.org ↗Article · Jan 2022 · 1 min read
In brief
In brief
Cross-sectional study of 22 pediatric patients demonstrates significant improvement in stool-related and overall quality of life three months after cecostomy tube insertion for refractory chronic constipation or fecal incontinence. Both organic (spina bifida, anorectal malformation, Hirschsprung) and functional diagnosis groups showed comparable QoL gains following ACE therapy.
Written by the GCMD Library team from the article.
Background
We compared patient- and family-reported overall and stool-related quality of life (QoL) before and after an antegrade continence enema (ACE) procedure (cecostomy tube insertion) for refractory chronic constipation or fecal incontinence (CCFI). We hypothesized that patients with functional diagnoses experience similar improvements in QoL compared to those with organic diagnoses.
Methods
This is a cross-sectional study of patients undergoing cecostomy tube insertion for CCFI at a tertiary pediatric hospital from 2012-2019. Patients and/or primary caregivers completed validated stooling and overall QoL surveys based on three time points: before surgery, three months after surgery, and at the time of survey / date of last follow-up. Repeated measures analyses compared scores over time between subjects and within the diagnostic groups.
Results
The response rate was 65% (22/34 patients, 12 organic and 10 functional diagnoses). Mean age was 8.3 years and 32% of the participants were female. Organic diagnoses were: spina bifida (6), anorectal malformation (5), and Hirschsprung Disease (1). There was substantial improvement in stool-related and overall QoL at three months post-ACE procedure (both p