Clinical outcomes following implementation of a management bundle for esophageal atresia with distal Tracheoesophageal fistula
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In brief
In brief
Multi-institutional study of 170 infants with Type-C EA/TEF demonstrates 2.5-fold increase in protocol bundle compliance without compromising safety outcomes. Key finding: eliminating transanastomotic tubes correlated with reduced stricture rates over time, challenging traditional practice patterns in EA/TEF repair.
Written by the GCMD Library team from the article.
Abstract
Background/Purpose
This study evaluated compliance with a multi-institutional quality improvement management protocol for Type-C esophageal atresia with distal tracheoesophageal fistula (EA/TEF).
Methods
Compliance and outcomes before and after implementation of a perioperative protocol bundle for infants undergoing Type-C EA/TEF repair were compared across 11 children's hospitals from 1/2016–1/2019. Bundle components included elimination of prosthetic material between tracheal and esophageal suture lines during repair, not leaving a transanastomotic tube at the conclusion of repair (NO-TUBE), obtaining an esophagram by postoperative-day-5, and discontinuing prophylactic antibiotics 24 h postoperatively.
Results
One-hundred seventy patients were included, 40% pre-protocol and 60% post-protocol. Bundle compliance increased 2.5-fold pre- to post-protocol from 17.6% to 44.1% (p < 0.001). After stratifying by institutional compliance with all bundle components, 43.5% of patients were treated at low-compliance centers (<20%), 43% at medium-compliance centers (20–80%), and 13.5% at high-compliance centers (>80%). Rates of esophageal leak, anastomotic stricture, and time to full feeds did not differ between pre- and post-protocol cohorts, though there was an inverse correlation between NO-TUBE compliance and stricture rate over time (ρ = −0.75, p = 0.029).
Conclusions
Compliance with our multi-institutional management protocol increased 2.5-fold over the study period without compromising safety or time to feeds and does not support the use of transanastomotic tubes.
Level of Evidence
Level II.
Type of Study
Treatment Study.