Article1 min read·Published Apr 2023Older

Chronic Mucosal Inflammation in Pediatric Intestinal Failure Patients-A Unique Phenomenon

Part of Short Bowel Syndrome & Intestinal Failure 8 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Introduction/Objectives: As intestinal failure (IF) management improves and long-term survival rate increases, its physiological complications have become more apparent. The development of chronic intestinal inflammation resembling inflammatory bowel disease (IBD) in this population has been reported, but the literature describing it in detail is sparse. The present study was designed to characterize children with IF who developed chronic intestinal inflammation and identify the potential predisposing clinical factors. Methods: This retrospective study was based on the electronic medical records of pediatric patients seen at the Cincinnati Children's Hospital Medical Center between January 2000 and July 2022. Demographic and medical history data were collected and compared between children with IF that developed chronic intestinal inflammation and children with IF that did not develop chronic intestinal inflammation. Results: During the follow-up period, 23 children were diagnosed with chronic intestinal inflammation. Of these, 12 (52%) were males, with a median age of 4.5 (3-7) years at diagnosis. Nearly one-third of the patients had gastroschisis (31%), followed by necrotizing enterocolitis (26%), and malrotation and volvulus (21.7%). More children in the chronic intestinal inflammation group lacked an ileocecal valve (ICV) and adjoining distal ileum as compared to the short bowel syndrome (SBS)-IF control group (15 patients, 65% vs 8 patients, 33%). Moreover, more children

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Article · Apr 2023 · 1 min read

In brief

This retrospective study characterizes chronic intestinal inflammation resembling IBD in 23 pediatric intestinal failure patients, identifying absence of the ileocecal valve as a potential predisposing factor. The cohort included children with gastroschisis, NEC, and malrotation, with median diagnosis age of 4.5 years.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

Chronic intestinal inflammation resembling inflammatory bowel disease has been reported in pediatric intestinal failure patients.
EstablishedIntroduction/Objectives
The study included pediatric patients seen at Cincinnati Children's Hospital Medical Center between January 2000 and July 2022.
ResearchMethods
Twenty-three children with intestinal failure were diagnosed with chronic intestinal inflammation during the follow-up period.
ResearchResults
The median age at diagnosis of chronic intestinal inflammation was 4.5 years (range 3-7 years).
ResearchResults
Gastroschisis was the most common underlying diagnosis in children with chronic intestinal inflammation (31%), followed by necrotizing enterocolitis (26%) and malrotation with volvulus (21.7%).
ResearchResults
Absence of the ileocecal valve and adjoining distal ileum was more common in children with chronic intestinal inflammation compared to short bowel syndrome-intestinal failure controls (65% vs 33%).
ResearchResults