Childhood-Onset Myasthenia Gravis Patients Benefited from Thymectomy in a Long-Term Follow-up Observation
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In brief
In brief
Retrospective study of 32 childhood-onset myasthenia gravis patients demonstrates significant clinical improvement following thymectomy during 5-year follow-up, measured by QMG and MG-ADL scores. Analysis identifies prognostic factors associated with both short-term and long-term surgical outcomes in pediatric patients.
Written by the GCMD Library team from the article.
Introduction The effect of thymectomy on the treatment of childhood-onset myasthenia gravis (CMG) remains debatable. The objective of this study was to evaluate the clinical outcome and relevant prognostic factors of thymectomy for CMG patients.
Materials and Methods A total of 32 CMG patients who underwent thymectomy before 18 years of age were included in this retrospective study. Clinical state following thymectomy was assessed by quantified myasthenia gravis (QMG) scores, myasthenia gravis–related activities of daily living (MG-ADL) scores, and Myasthenia Gravis Foundation of America postintervention status. Repeated-measures analysis of variance (ANOVA) examined the changes in postoperative scores during the 5-year follow-up. Univariate logistic regression was applied to identify factors associated with short-term (1-year postoperation) and long-term (5-year postoperation) clinical outcomes.
Results Repeated-measures ANOVA showed that QMG scores (F = 6.737, p