Alberto Tozzi · Central nervous system immunological complications of immunotherapy in pediatrics.
Article1 min read·Published Oct 2026

Central nervous system immunological complications of immunotherapy in pediatrics.

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Article · Oct 2026 · 1 min read

In brief

In brief

This review examines central nervous system immune-related adverse events in pediatric patients receiving immunotherapies including CAR T-cells and checkpoint inhibitors. The article synthesizes current evidence on CNS complications that are increasingly recognized but remain incompletely characterized in children.

Written by the GCMD Library team from the article.

Alberto Tozzi

Immunotherapies such as CAR T-cell therapy and immune checkpoint inhibitors (ICIs) have transformed pediatric cancer treatment but are increasingly associated with severe central nervous system (CNS) immune-related adverse events (irAEs), which remain poorly understood in children. This review summarizes current knowledge on CNS irAEs in children receiving CAR T-cells, ICIs, and monoclonal antibod…

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