Bariatric Surgery and Kidney Disease Outcomes in Severely Obese Youth
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In brief
In brief
Review examining the nephroprotective effects of bariatric surgery in severely obese adolescents with and without type 2 diabetes. Discusses mechanisms of kidney disease improvement following Roux-en-Y gastric bypass versus vertical sleeve gastrectomy, and explores future non-surgical therapeutic approaches.
Written by the GCMD Library team from the article.
Publication date: Available online 20 January 2020
Source: Seminars in Pediatric Surgery
Author(s): Petter Bjornstad, Edward Nehus, Daniel van Raalte
Abstract
Bariatric surgery, an emerging treatment for severely obese youth with and without T2D, provides marked improvement in insulin resistance, beta-cell function, and central adiposity. Further, preliminary data suggest that bariatric surgery also results in significant improvement in markers of obesity-related nephropathy and DKD, beyond that which can be achieved with current medical interventions. Yet, the mechanisms whereby bariatric surgery attenuates kidney disease remain unclear. This review summarizes the data on the effects of bariatric surgery on obesity-related nephropathy and DKD in youth with and without T2D, in addition to potential mechanisms underlying the nephroprotective effects of weight loss surgery and how these may differ in Roux-en-Y gastric bypass vs. vertical sleeve gastrectomy. Finally, we discuss potential future non-surgical therapies to mitigate kidney disease.