Associated Anomalies in Congenital Lung Abnormalities: A 20-Year Experience
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Oct 2020 · 1 min read
In brief
In brief
This 20-year retrospective study of 196 congenital lung abnormality patients found 14% had major associated anomalies, most commonly cardiac (32%) and gastrointestinal (18%) defects. Lung agenesis and bronchogenic cysts showed highest association rates. Findings support targeted cardiovascular and GI screening with chest/abdominal radiography for all CLA newborns.
Written by the GCMD Library team from the article.
Introduction: A congenital lung abnormality (CLA) is often found in conjunction with other abnormalities but screening guidelines for newborns with CLA have not yet been reported. We aimed to assess the incidence of associated anomalies in CLA patients born or followed up at our centre and the need for additional screening of newborns with a CLA. Methods: From a retrospective chart review of all patients born with a CLA between January 1999 and January 2019, we identified patients diagnosed with a congenital pulmonary airway malformation, bronchopulmonary sequestration, congenital lobar overinflation, bronchogenic cyst, or lung agenesis. Associated anomalies were noted and categorized according to the affected organ system. Results: Twenty-eight (14%) of 196 CLA patients had a major associated anomaly. This was most frequent in conjunction with a lung agenesis (100%) or bronchogenic cyst (29%). Congenital heart defects (32%) and gastrointestinal defects (18%) were the most frequently associated anomalies. Examination of newborns with a CLA should focus on the cardiovascular and gastrointestinal tract, and a chest and abdominal radiograph may be useful to assess signs of major associated anomalies, regardless of the clinical course. Keywords: Congenital cystic adenomatoid malformation; Congenital lung disease; Congenital pulmonary airway malformation; Lung malformation; Paediatric pulmonology.
DOI: 10.1159/000509426