StayCurrentMD · ANTITHROMBIN SUPPLEMENTATION FOR PREVENTION OF VASCULAR THROMBOSIS AFTER PEDIATRIC LIVER TRANSPLANTATION
Article1 min read·Published Jul 2022Older

ANTITHROMBIN SUPPLEMENTATION FOR PREVENTION OF VASCULAR THROMBOSIS AFTER PEDIATRIC LIVER TRANSPLANTATION

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Article · Jul 2022 · 1 min read

In brief

In brief

Study examines thrombotic and hemorrhagic complications in pediatric liver transplant recipients receiving antithrombin and fresh frozen plasma supplementation. Post-transplant coagulation imbalance creates prothrombotic risk as the graft synthesizes clotting factors at different rates, necessitating targeted prophylactic strategies.

Written by the GCMD Library team from the article.

After liver transplantation (LT), synthesis of coagulation factors by the graft recovers faster for pro-thrombotic than anti-thrombotic factors, resulting in a potential pro-thrombotic imbalance. We studied the thrombotic and hemorrhagic complications in our pediatric LT series, providing supplementation of fresh frozen plasma (FFP) and/or antithrombin (AT) in the prophylactic antithrombotic regimen.

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