A single institution experience of Eppikajutsuto for the treatment of lymphatic malformations in children
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In brief
In brief
Single-center retrospective study of 10 pediatric patients with lymphatic malformations treated with Eppikajutsuto (TJ-28) herbal medicine demonstrates 83% median response rate with most improvement occurring within first six months. Treatment showed particular efficacy for cervical lesions and airway symptoms, offering a non-surgical alternative for pediatric LM management.
Written by the GCMD Library team from the article.
Background
Eppikajutsuto (TJ-28) is an herbal medicine recently reported to be effective in treating lymphatic malformations (LMs). We report our experience concerning the clinical efficacy of TJ-28 for LMs.
Methods
Medical records of 10 LM cases treated with TJ-28 between 2016 and 2018 were reviewed. TJ-28 was given at 0.3 g/kg/day and then increased to 0.5 if no improvement was noted after the first three months of treatment. Their clinical data were collected, and LM volume indices (depth×width×height) were measured with the first (LMVI-F) and latest (LMVI-L) imaging studies. The response rates were calculated as 1-LMVI-L / LMVI-F (%).
Results
The median age at the diagnosis and treatment period was 1.5 years and 17.5 months, respectively. LMs were located in the neck (six), mesenterium or retroperitoneum (three), and inguinal region (one). The median response rate was 83%, including 100% in three cases and the apparent improvement of obstructive airway symptoms in one case. One case underwent surgery for insufficient improvement, and another that showed no effect is being considered for surgery. Most of the satisfactory outcomes were demonstrated in the first six months of treatment.
Conclusion
TJ-28 seems to be effective in treating LMs in children, especially early in treatment.
Level of evidence
IV