A population-based analysis of pediatric breast cancer
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In brief
In brief
Population-based analysis of 134 pediatric breast cancer cases from 1973-2014 using SEER data. Study examines demographic trends, histologic subtypes (carcinoma, fibroepithelial tumors, sarcoma), and five-year survival outcomes, with notable racial disparities in tumor distribution.
Written by the GCMD Library team from the article.
Purpose
The purpose of this study was to evaluate trends in demographics and outcomes of pediatric breast cancer in a United States population-based cohort.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify all pediatric patients with malignant breast tumors between 1973 and 2014. Analysis was performed using Stata Statistical Software version 13.1. Associations between categorical variables were made using X2 test. Log-rank test was used for univariate survival analysis. Kaplan–Meier analysis investigated five-year survival rates across several variables. Adjusted analysis was performed using a Cox Proportional-Hazards regression.
Results
134 patients with breast malignancies were identified. Carcinoma was the most prevalent histology (48.5%), followed by fibroepithelial tumors (FETs) (35.1%), and sarcoma (14.2%). FETs were twice as common in black compared to nonblack patients (56.3% vs. 29.0%, p