A comparison of small bowel and fecal microbiota in children with short bowel syndrome
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In brief
In brief
Comparative study examining gut microbiota differences in infants with short bowel syndrome, analyzing both fecal samples and small bowel specimens using 16S rRNA sequencing and qPCR. Research distinguishes between patients with colon in continuity versus those with small bowel ostomy to understand microbial disturbances affecting gut function in SBS.
Written by the GCMD Library team from the article.
Background
Babies with short bowel syndrome (SBS) have small intestinal microbial disturbances that impact gut function. Characterizing the small bowel microbiota is challenging, and the utility of sampling stool is unclear. This study compares the microbiota from fecal samples and the small bowel.
Methods
Stool samples were collected (2016–2017) from infants with SBS and colon in continuity (COLON) or SBS with small bowel ostomy (sbSTOMA). The abundance and quantity of major bacterial genera was compared between groups and to healthy controls using 16S rRNA sequencing and qPCR. Kruskall-Wallis test was used for analysis with P values