A Case Series of Iatrogenic Gastrointestinal Perforations in Premature Infants Below 30 Weeks’ Gestation

jpedsurg.org

Iatrogenic gastrointestinal perforations (IGP) in preterm newborns are rare, but life-threatening events. This report describes a case series of IGP who were admitted to one of the largest Neonatal Intensive Care Units (NICU) in the Netherlands. The aim of the study was to report on incidence, clinical presentation, mortality and long-term outcome.

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Article · Aug 2025 · 1 min read

In brief

This case series examines iatrogenic gastrointestinal perforations in extremely premature infants (<30 weeks gestation) treated at a major Dutch NICU. The study analyzes incidence rates, clinical presentations, mortality outcomes, and long-term developmental follow-up for this rare but critical complication.

Iatrogenic GI perforations in preterm infants <30 weeks are rare but carry high mortality risk requiring urgent surgical intervention.
Early recognition of perforation signs (abdominal distension, pneumoperitoneum) is critical in NICU settings to improve survival outcomes.
Case series data helps establish incidence rates and risk factors for IGP in extremely premature populations managed in tertiary NICUs.

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