Mesenchymal Stem Cells Attenuates Hirschsprung diseases - Associated Enterocolitis by Reducing M1 Macrophages Infiltration via COX-2 Dependent Mechanism

This study evaluates mesenchymal stem cell therapy as a treatment for Hirschsprung disease-associated enterocolitis, a serious postoperative complication. The research demonstrates that MSCs reduce inflammatory M1 macrophage infiltration through a COX-2-dependent mechanism, offering potential for safer long-term management of this life-threatening condition.