Dysregulation of CITED2 in abnormal lung development in the nitrofen rat model

This study investigates CITED2 gene expression patterns during abnormal lung development in a rat model of congenital diaphragmatic hernia (CDH). Researchers found stage-specific dysregulation of CITED2, with reduced expression at E18 and increased expression at E21, suggesting this transcription factor plays a critical role in the pulmonary hypoplasia associated with CDH.