mRNA sequencing provides new insights into the pathogenesis of Hirschsprung’s disease in mice

This study uses mRNA sequencing to identify 8,354 differentially expressed genes in EDNRB-mutant mouse models of Hirschsprung disease, revealing axon guidance and focal adhesion pathways as key mechanisms in disease pathogenesis. The findings provide molecular insights into enteric nervous system development defects underlying this congenital disorder.