Polyphyllin D induces necroptosis in neuroblastoma cells (IMR-32 and LA-N-2) in mice

This preclinical study demonstrates that polyphyllin D, derived from Paris polyphylla, suppresses neuroblastoma tumor growth in mouse models by inducing necroptosis through RIPK3 pathway activation. The compound showed antitumor activity in both IMR-32 and LA-N-2 cell lines, suggesting potential as a novel therapeutic approach for pediatric neuroblastoma.