Fetal lung hypoxia and energetic cell failure in the nitrofen-induced congenital diaphragmatic hernia rat model

This study demonstrates that fetal lungs in the nitrofen-induced CDH rat model experience chronic hypoxia and cellular energy failure, with disrupted ATP ratios and compensatory upregulation of metabolic enzymes. The findings suggest mitochondrial dysfunction may contribute to abnormal lung development in CDH, potentially opening avenues for novel mitochondria-targeted therapies.