Surgical Factors Influencing Local Relapse and Outcome in the Treatment of Unilateral Nephroblastoma

Large retrospective analysis of 2,386 unilateral nephroblastoma patients identifies age >48 months, tumor volume >500mL, histology, and inadequate lymph node sampling as key risk factors for local relapse. Local recurrence significantly increases metastasis risk and mortality, emphasizing the critical importance of complete lymph node sampling during initial surgery to improve outcomes.