Synthetic versus Biological Patches for CDH: A Comparison of Recurrence Rates and Adverse Events, Systematic Review, and Meta-Analysis

Systematic review comparing synthetic versus biological patches for CDH repair in pediatric patients shows synthetic patches have lower recurrence rates (16.7% vs 30.3%) but higher skeletal deformity risk. PTFE demonstrated 11.5% recurrence compared to 33.3% for SIS-based biological patches, though newer biological materials may perform better than historical SIS data suggests.