Effect of N-Acetylserotonin on TLR-4 and MyD88 Expression during Intestinal Ischemia-Reperfusion in a Rat Model

Rat model study demonstrates that N-acetylserotonin (NAS) treatment significantly reduces intestinal mucosal damage following ischemia-reperfusion by downregulating TLR-4, MyD88, and TRAF6 expression in the innate immune pathway. Findings suggest NAS may offer therapeutic potential for conditions involving intestinal IR injury, including necrotizing enterocolitis.