Pathways and microbiome modifications related to surgery and enterocolitis in Hirschsprung disease

Study of 31 Hirschsprung patients reveals surgery causes significant gut microbiome disruption, with Bacteroidetes decreasing and Proteobacteria increasing post-operatively. Proteobacteria and specific virulence factors strongly correlate with HAEC development, suggesting microbiome-targeted therapies may prevent this serious complication.