KDM5B promotes cell migration by regulating the noncanonical Wnt/PCP pathway in Hirschsprung’s disease

Research identifies KDM5B histone demethylase as a key regulator of neuronal migration in Hirschsprung's disease, with reduced expression in aganglionic bowel segments. Study demonstrates KDM5B promotes cell migration through the noncanonical Wnt/PCP signaling pathway, offering potential therapeutic targets for this congenital disorder.