Esophageal dysmotility: An intrinsic feature of megacystis, microcolon, hypoperistalsis syndrome (MMIHS)

Case series of six MMIHS patients reveals esophageal dysmotility as a consistent feature, with absent peristalsis on manometry and megaesophagus developing with age. All patients required enteral feeding support despite treatment of secondary findings like eosinophilic esophagitis, suggesting esophageal involvement is intrinsic to this smooth muscle disorder.