Reduced expression of the NLRP6 inflammasome in the colon of patients with Hirschsprung’s disease

Study demonstrates significantly reduced NLRP6 inflammasome expression in both aganglionic and ganglionic colon segments of Hirschsprung's disease patients compared to controls. Findings suggest NLRP6 dysregulation may contribute to altered intestinal immunity and microbiome disruption underlying Hirschsprung's-associated enterocolitis pathogenesis.