Antibacterial and Anti-Inflammatory Effects of Lactobacillus reuteri in its Biofilm State Contribute to its Beneficial Effects in a Rat Model of Experimental Necrotizing Enterocolitis

Study demonstrates that Lactobacillus reuteri in biofilm form significantly reduces necrotizing enterocolitis incidence in premature rat models (67% to 18%), requiring both antimicrobial reuterin and anti-inflammatory histamine properties for efficacy. Findings suggest NEC pathogenesis involves both infectious and inflammatory mechanisms.