Updates on Bacterial Resistance and Empirical Antibiotics Treatment of Complicated Acute Appendicitis in Children

Five-year retrospective study of 257 pediatric appendicitis cases reveals significant increase in antibiotic-resistant bacteria (42.1% of complicated cases), particularly ESBL E. coli and Pseudomonas. Piperacillin-tazobactam provided best coverage (69.8%) against resistant strains, while early antibiotic escalation showed no benefit in reducing complications or treatment duration.