Overexpression Prox1 in HemECs resembles Kaposiform hemangioendothelioma and cytotoxicity of sirolimus in vitro

Researchers established a Prox1-overexpressing cell line that mimics kaposiform hemangioendothelioma behavior, demonstrating increased proliferation and invasion. Sirolimus treatment inhibited cell growth through mTOR pathway blockade and autophagy induction, providing mechanistic insight into its therapeutic efficacy for this rare pediatric vascular tumor.