A new method of primary engineering of esophagus using orthotopic in-body tissue architecture

Novel orthotopic in-body tissue architecture technique enables primary esophageal reconstruction by interposing a tubular mold at the defect site, eliminating the need for second-stage surgery. Rat model demonstrates successful regeneration of esophageal epithelium and collagenous wall after four weeks, offering potential treatment for long-gap esophageal atresia.