Whole Blood is Superior to Component Transfusion for Injured Children: A Propensity Matched Analysis

Propensity-matched study of 56 injured children demonstrates that low-titer O-negative whole blood transfusion achieves faster shock resolution and improved coagulation compared to conventional component therapy, with reduced plasma and platelet requirements. Whole blood recipients showed significantly faster base deficit correction and lower post-resuscitation INR without differences in mortality or hospital outcomes.