A novel model of injured liver ductal organoids to investigate cholangiocyte apoptosis with relevance to biliary atresia

Researchers developed a novel ex vivo model using mouse liver ductal organoids to study cholangiocyte injury and apoptosis relevant to biliary atresia. Acetaminophen-induced injury triggered fibrogenic cytokine expression and increased apoptosis, demonstrating the model's potential for investigating early fibrogenic cascades and developing new BA therapies.