LncRNA HCP5 promotes neuroblastoma proliferation by regulating miR-186-5p/MAP3K2 signal axis

This study identifies lncRNA HCP5 as a key driver of neuroblastoma proliferation through a competitive endogenous RNA mechanism. HCP5 binds miR-186-5p, preventing it from suppressing MAP3K2, thereby promoting tumor growth—a pathway validated in cell lines and mouse models that offers potential diagnostic and therapeutic targets.